The ZEB1 Monoclonal Antibody is a valuable tool for researchers studying the role of ZEB1, a key transcription factor involved in the regulation of epithelial-mesenchymal transition (EMT) and tumor metastasis. This antibody, produced through hybridoma technology, is highly specific to human ZEB1 and has been validated for use in immunofluorescence and immunohistochemistry applications.ZEB1 is known to play a critical role in cancer progression by promoting tumor cell invasion and metastasis through the induction of EMT. Its aberrant expression has been linked to poor prognosis in various cancer types, making it an attractive target for therapeutic intervention.
The ZEB1 Monoclonal Antibody enables detection and visualization of ZEB1 expression in tumor samples, providing valuable insights into the molecular mechanisms driving cancer metastasis.By studying the activity of ZEB1 using this antibody, researchers can gain a better understanding of its role in tumor progression and identify potential therapeutic strategies to target ZEB1-mediated pathways. In addition, this antibody can also be used to explore the involvement of ZEB1 in other biological processes, shedding light on its broader functions beyond cancer biology.
Product Name:
ZEB1 Monoclonal Antibody
SKU:
CAB21794
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 800-900 of human ZEB1 (NP_110378.3).
This gene encodes a zinc finger transcription factor. The encoded protein likely plays a role in transcriptional repression of interleukin 2. Mutations in this gene have been associated with posterior polymorphous corneal dystrophy-3 and late-onset Fuchs endothelial corneal dystrophy. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
6935
Clone Number:
ARC53599
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of HeLa cells, using ZEB1 antibody (CAB21794) at1:2000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
