The ZDHHC23 Polyclonal Antibody (PAC037898) is a valuable tool for researchers studying ZDHHC23, a crucial enzyme involved in palmitoylation, a process essential for the function of various proteins. This antibody, generated in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ZDHHC23 protein, this antibody enables researchers to detect and analyze its expression in different cell types, making it ideal for studies in biochemistry and molecular biology.
ZDHHC23, a member of the DHHC family of palmitoyltransferases, plays a key role in the regulation of protein localization and function through the addition of lipid modifications. Dysregulation of ZDHHC23 activity has been linked to various diseases, including neurological disorders and cancer, making it a promising target for therapeutic intervention. Understanding the function of ZDHHC23 is essential for uncovering its role in disease pathogenesis and developing novel treatment strategies.
Western blot. All lanes: ZDHHC23 antibody at 8µg/ml. Lane 1: 293T whole cell lysate. Lane 2: Mouse brain tissue. Lane 3: A549 whole cell lysate. Lane 4: Human placenta tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 46 kDa. Observed band size: 46 kDa.
Immunofluorescent analysis of 293T cells using PACO37898 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human colon cancer using PACO37898 at dilution of 1:100.
Background:
Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane. May be involved in NOS1 regulation and targeting to the synaptic membrane.
ZDHHC23: May be involved in NOS1 regulation and targeting to the synaptic membrane. Belongs to the DHHC palmitoyltransferase family.Protein type: Adaptor/scaffold; EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; TransferaseChromosomal Location of Human Ortholog: 3q13.31
