The ZDHHC12 Polyclonal Antibody (PACO38154) is a valuable tool for researchers studying ZDHHC12, a palmitoyl transferase enzyme involved in protein palmitoylation, a critical post-translational modification. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, and has been validated for use in Western blot applications.ZDHHC12 plays a key role in the regulation of protein localization, stability, and function through the addition of palmitate groups. Dysregulation of palmitoylation has been associated with various diseases, including cancer, neurological disorders, and metabolic conditions. Therefore, understanding the function of ZDHHC12 is essential for unraveling the molecular mechanisms underlying these pathologies.
By targeting ZDHHC12, researchers can investigate its role in cellular signaling pathways, protein-protein interactions, and disease progression. The ZDHHC12 Polyclonal Antibody enables precise detection and analysis of ZDHHC12 protein levels in different cell types, making it a valuable tool for studies in cell biology, molecular biology, and drug discovery.Unlocking the mysteries of ZDHHC12 function may lead to the development of novel therapeutic strategies for a range of diseases, providing new hope for patients in need of effective treatments.
Western blot. All lanes: ZDHHC12 antibody at 0.4µg/ml + A431 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 31, 25, 37 kDa. Observed band size: 37 kDa.
Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO38154 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO38154 at dilution of 1:100.
Background:
endoplasmic reticulum, Golgi apparatus, palmitoyltransferase activity, protein-cysteine S-palmitoyltransferase activity, peptidyl-L-cysteine S-palmitoylation, protein palmitoylation, protein targeting to membrane
Synonyms:
Probable palmitoyltransferase ZDHHC12 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 12) (DHHC-12) (Zinc finger protein 400), ZDHHC12, ZNF400
UniProt Protein Function:
ZDHHC12: Belongs to the DHHC palmitoyltransferase family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transferase; EC 2.3.1.225Chromosomal Location of Human Ortholog: 9q34.11Cellular Component: endoplasmic reticulum; Golgi apparatus; integral to membraneMolecular Function: palmitoyltransferase activity; protein-cysteine S-palmitoleyltransferase activity; zinc ion bindingBiological Process: protein palmitoylation
