The ZC3H8 Polyclonal Antibody (PAC023500) is a valuable tool for researchers studying ZC3H8, a protein involved in RNA metabolism and cell signaling pathways. This antibody is raised in rabbits and has high reactivity with human samples, making it ideal for use in Western blot applications. By binding specifically to the ZC3H8 protein, this antibody allows for the accurate detection and analysis of ZC3H8 in various cell types.ZC3H8 is known to play a crucial role in the regulation of gene expression and cell growth, making it a key player in processes such as RNA processing, mRNA stability, and translation.
Dysregulation of ZC3H8 has been implicated in various diseases, including cancer and neurological disorders, making it an important target for research. Understanding the function and mechanisms of ZC3H8 can provide valuable insights into disease pathology and potential therapeutic strategies.Overall, the ZC3H8 Polyclonal Antibody is a reliable tool for researchers looking to study the role of ZC3H8 in cellular processes and disease development. Its high specificity and reactivity make it a valuable asset for studies in molecular biology, cell biology, and disease research.
Synthesized peptide derived from internal of human ZC3H8.
Form:
Liquid
Storage Buffer:
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Western blot analysis of extracts from HepG2 cells, using ZC3H8 antibody.
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using ZC3H8 antibody.
Background:
Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene By similarity. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.
Synonyms:
Zinc finger CCCH domain-containing protein 8; ZC3H8; ZC3HDC8;
UniProt Protein Function:
ZC3H8: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 2q13Cellular Component: Cajal body; nucleoplasm; nucleus; transcription elongation factor complexMolecular Function: protein binding; sequence-specific DNA binding; transcription factor activityBiological Process: negative regulation of T cell differentiation in the thymus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase III promoter; response to antibiotic; snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter; T cell homeostasis
