The ZC3H8 Polyclonal Antibody (PACO00808) is a valuable tool for researchers studying the ZC3H8 protein, which plays a critical role in various cellular processes including gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to the ZC3H8 protein, researchers can accurately detect and analyze its expression levels in different cell types.
ZC3H8 is a key player in RNA metabolism and has been implicated in diseases such as cancer and neurodegenerative disorders. Its functions in post-transcriptional gene regulation make it a promising target for further investigation in the fields of molecular biology and disease research. By studying the role of ZC3H8, researchers can gain insights into its involvement in various pathological conditions and potentially identify new therapeutic targets for treatment.
Antibody Name:
ZC3H8 Antibody
Antibody SKU:
PACO00808
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human
Immunogen:
synthesized peptide derived from the Internal region of human Fliz1.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
ZC3H8; ZC3HDC8; Zinc finger CCCH domain-containing protein 8
UniProt Protein Function:
ZC3H8: Acts as a transcriptional repressor of the GATA3 promoter. Sequence-specific DNA-binding factor that binds to the 5'-AGGTCTC-3' sequence within the negative cis-acting element intronic regulatory region (IRR) of the GATA3 gene. Induces thymocyte apoptosis when overexpressed, which may indicate a role in regulation of thymocyte homeostasis.Protein type: DNA-bindingChromosomal Location of Human Ortholog: 2q13Cellular Component: Cajal body; nucleoplasm; nucleus; transcription elongation factor complexMolecular Function: protein binding; sequence-specific DNA binding; transcription factor activityBiological Process: negative regulation of T cell differentiation in the thymus; negative regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase III promoter; response to antibiotic; snRNA transcription from RNA polymerase II promoter; snRNA transcription from RNA polymerase III promoter; T cell homeostasis
