Kaiso/ZBTB33 Rabbit Polyclonal Antibody (CAB12856)
- SKU:
- CAB12856
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Description
Product Name: | Kaiso/ZBTB33 Rabbit Polyclonal Antibody |
SKU: | CAB12856 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 523-672 of human Kaiso/Kaiso/ZBTB33 (NP_006768.1). |
Sequence: | PCRY CEKV FPLA EYRT KHEI HHTG ERRY QCLA CGKS FINY QFMS SHIK SVHS QDPS GDSK LYRL HPCR SLQI RQYA YLSD RSST IPAM KDDG IGYK VDTG KEPP VGTT TSTQ NKPM TWED IFIQ QEND SIFK QNVT DGST EFEF IIPE SY |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:1000 - 1:3000 IHC-P,1:100 - 1:500 |
Synonyms: | ZNF348; ZNF-kaiso; Kaiso/ZBTB33 |
Positive Sample: | A-431,Mouse kidney |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 74kDa |
Observed MW: | 74kDa |
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.
Purification Method: | Affinity purification |
Gene ID: | 10009 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |