The ZBTB32 Polyclonal Antibody (PACO42854) is a vital tool for researchers studying the ZBTB32 protein, a transcription factor involved in regulating gene expression and cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ZBTB32 protein, researchers can effectively detect and analyze its presence in various cell types, making it an essential component for investigations in molecular biology and developmental biology.ZBTB32, also known as a zinc finger and BTB domain-containing protein 32, plays a pivotal role in controlling gene transcription and is implicated in diverse biological functions, including cell proliferation, differentiation, and apoptosis.
Its importance in regulating cellular processes makes it a valuable target for research in areas such as cancer biology, developmental biology, and neurobiology. By gaining insight into the functions of ZBTB32, researchers can potentially uncover new therapeutic targets and treatment strategies for various diseases and disorders.Overall, the ZBTB32 Polyclonal Antibody (PACO42854) offers researchers a reliable tool to study the functions of the ZBTB32 protein and its impact on cellular processes, paving the way for advancements in biomedical research and potentially leading to the development of innovative therapeutic interventions.
Western blot. All lanes: ZBTB32 antibody at 4µg/ml. Lane 1: Mouse brain tissue. Lane 2: Jurkat whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 53 kDa. Observed band size: 53 kDa.
Immunohistochemistry of paraffin-embedded human testis tissue using PACO42854 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO42854 at dilution of 1:100.
Background:
DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).
Synonyms:
Zinc finger and BTB domain-containing protein 32 (FANCC-interacting protein) (Fanconi anemia zinc finger protein) (Testis zinc finger protein) (Zinc finger protein 538), ZBTB32, FAZF TZFP ZNF538
UniProt Protein Function:
ZBTB32: DNA-binding protein that binds to the to a 5'- TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells. Belongs to the krueppel C2H2-type zinc-finger protein family.Protein type: DNA-binding; C2H2-type zinc finger proteinChromosomal Location of Human Ortholog: 19q13.1Cellular Component: nucleoplasm; nucleusMolecular Function: DNA binding; protein binding; transcription corepressor activity; zinc ion bindingBiological Process: DNA damage response, detection of DNA damage; negative regulation of transcription from RNA polymerase II promoter; transcription from RNA polymerase II promoter
