ZBED3 Antibody (PACO63175)
- SKU:
- PACO63175
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
ZBED3 Antibody (PACO63175)
The ZBED3 Polyclonal Antibody (PACO63175) is a valuable tool for research involving ZBED3, a transcription factor involved in regulating gene expression and cellular processes. This antibody, generated in rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the ZBED3 protein, this antibody allows for the detection and analysis of ZBED3 in various cell types, making it an ideal choice for studies in molecular biology and developmental biology.ZBED3 is known for its role in regulating gene expression, particularly in the context of growth and development. It is involved in controlling the expression of genes that are critical for cellular processes, making it a key player in the regulation of various biological pathways.
Research into the function of ZBED3 is important for understanding its role in health and disease, as dysregulation of ZBED3 has been implicated in various disorders, including cancer and developmental abnormalities.By using the ZBED3 Polyclonal Antibody (PACO63175), researchers can gain valuable insights into the mechanisms by which ZBED3 influences gene expression and cellular processes. This antibody provides a reliable tool for studying ZBED3 and its function, enabling further advancements in our understanding of this important transcription factor.
| Antibody Name: | ZBED3 Antibody (PACO63175) |
| Antibody SKU: | PACO63175 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Zinc finger BED domain-containing protein 3 protein (1-234AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO63175 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression (By similarity). |
| Synonyms: | Zinc finger BED domain-containing protein 3 (Axin-interacting protein), ZBED3 |
| UniProt Protein Function: | ZBED3: Acts as a positive regulator in the activation of the canonical Wnt/beta-catenin signaling pathway by stabilizing cytoplasmic beta-catenin. Involved in transcription activation of Wnt target gene expression. Interacts with AXIN1; the interaction is direct, enhanced by protein kinase GSK3B and casein kinase CSNK1E activities and decreases GSK3B-induced beta-catenin serine and threonine phosphorylations |
| UniProt Protein Details: | Protein type:DNA-binding Chromosomal Location of Human Ortholog: 5q13.3 Cellular Component: membrane; cytosol Molecular Function:DNA binding; metal ion binding Biological Process: Wnt receptor signaling pathway; negative regulation of protein amino acid phosphorylation; protein stabilization; positive regulation of transcription from RNA polymerase II promoter |
| UniProt Code: | Q96IU2 |
| NCBI GenInfo Identifier: | 14150185 |
| NCBI Gene ID: | |
| NCBI Accession: | NP_115743 |
| Molecular Weight: | |
| NCBI Full Name: | zinc finger BED domain-containing protein 3 |
| UniProt Protein Name: | Zinc finger BED domain-containing protein 3 |
| UniProt Synonym Protein Names: | Axin-interacting protein |
| UniProt Gene Name: | ZBED3Â Â |
| UniProt Entry Name: | ZBED3_HUMAN |
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