The ZAK Polyclonal Antibody (CAB7371) is a valuable tool for research involving the protein kinase ZAK, which plays a crucial role in cellular signaling pathways and stress response. This antibody, raised in rabbits, demonstrates high reactivity with human samples and is specifically validated for use in Western blot applications. By binding to ZAK, this antibody allows for detection and analysis of the protein in various cell types, making it an ideal choice for studies in cell signaling, inflammation, and cancer research.
ZAK, also known as sterile alpha motif and leucine zipper-containing kinase AZK, is involved in regulating cell growth, differentiation, and apoptosis in response to environmental stressors. Its involvement in cellular stress response pathways makes it a key target for research into diseases such as cancer, neurodegenerative disorders, and cardiovascular diseases. Understanding the function of ZAK is essential for uncovering potential therapeutic targets and developing treatments for these conditions.
Product Name:
ZAK Rabbit Polyclonal Antibody
SKU:
CAB7371
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-330 of human ZAK (NP_598407.1).
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
51776
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZAK Rabbit pAb (CAB7371) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
