The ZAK Polyclonal Antibody (CAB14513) is a vital tool for researchers studying the ZAK protein, a key regulator of cell signaling pathways involved in various cellular processes. Raised in rabbits, this antibody exhibits high reactivity to human samples and is validated for use in Western blot applications. By specifically binding to the ZAK protein, researchers can effectively detect and analyze its expression in different cell types, making it an invaluable asset for studies in cell biology and molecular biology.ZAK, also known as sterile alpha motif and leucine zipper containing kinase, plays a crucial role in regulating cell proliferation, apoptosis, and stress response pathways.
Its involvement in these fundamental cellular processes positions it as a promising target for research into cancer, neurodegenerative diseases, and inflammatory disorders. The ZAK Polyclonal Antibody provides researchers with a reliable tool to investigate the function and regulation of ZAK, paving the way for advances in drug development and therapeutic interventions targeting ZAK-related pathways.
Product Name:
ZAK Rabbit Polyclonal Antibody
SKU:
CAB14513
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 100-312 of human ZAK (NP_598407.1).
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
51776
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using ZAK Rabbit pAb (CAB14513) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
