The Zak Antibody (PACO4573) is a high-quality polyclonal antibody designed for research involving Zak, a protein implicated in immune regulation and cell signaling pathways. Raised in rabbits, this antibody is highly reactive with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.Zak, also known as sterile alpha motif and leucine zipper containing kinase AZK, is a key player in cell proliferation, apoptosis, and stress response. Its role in cell signaling makes it a valuable target for studies in cancer research, inflammation, and signal transduction pathways.
The Zak Antibody enables researchers to detect and analyze Zak protein levels in different cell types, allowing for a better understanding of its function and potential therapeutic applications.By utilizing the Zak Antibody in your research, you can further explore the mechanisms by which Zak influences cellular processes and potentially uncover new insights into disease development and treatment strategies. Whether studying cancer biology, immune regulation, or signal transduction, this antibody is a valuable tool for advancing your research efforts.
Antibody Name:
ZAK Antibody
Antibody SKU:
PACO04573
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from human MLTK around the non-phosphorylation site of S165.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixe
UniProt Protein Function:
ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; TKL group; MLK family; MLK subfamilyChromosomal Location of Human Ortholog: 2q24.2Cellular Component: cytoplasm; nucleusMolecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP bindingBiological Process: cell death; activation of MAPKK activity; positive regulation of apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of JNK activity; cell proliferation; response to radiation; DNA damage checkpoint; response to stress; cell differentiation; cell cycle arrest; cell cycle checkpoint
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Mitogen-activated protein kinase kinase kinase MLT
NCBI Synonym Full Names:
NCBI Official Symbol:
ZAKÂ Â
NCBI Official Synonym Symbols:
pk; AZK; MLT; MRK; MLK7; MLTK; mlklak Â
NCBI Protein Information:
mitogen-activated protein kinase kinase kinase MLT; HCCS-4; mixed lineage kinase 7; mixed lineage kinase-related kinase MRK-beta; human cervical cancer suppressor gene 4 protein; MLK-like mitogen-activated protein triple kinase; mixed lineage kinase with a leucine zipper and a sterile alpha motif
UniProt Protein Name:
Mitogen-activated protein kinase kinase kinase MLT
UniProt Synonym Protein Names:
Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK
