The ZAK Polyclonal Antibody (PACO1072) is a valuable tool for researchers studying the ZAK protein, which is known for its role in cell signaling and inflammation. This antibody, raised in rabbits, has high reactivity with human samples and has been validated for use in Western blot applications.ZAK, also known as sterile alpha motif and leucine zipper containing kinase, is involved in various cellular processes, including cell growth, differentiation, and apoptosis. By targeting the ZAK protein, this antibody enables researchers to detect and analyze its expression in different cell types, making it suitable for studies in immunology, cancer research, and inflammatory conditions.
The importance of ZAK in regulating cell signaling pathways and inflammatory responses highlights its potential as a therapeutic target for diseases such as cancer, autoimmune disorders, and inflammatory conditions. Understanding the function of ZAK is crucial for developing targeted therapies that modulate cell signaling and inflammation in these disease contexts.Overall, the ZAK Polyclonal Antibody is a valuable tool for researchers investigating the role of ZAK in cellular processes and disease pathogenesis, offering insights into potential therapeutic strategies for a range of conditions.
Antibody Name:
ZAK Antibody
Antibody SKU:
PACO01072
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IF
Recommended Dilutions:
WB:1:500-1:2000, IF:1:200-1:1000
Species Reactivity:
Human, Mouse
Immunogen:
synthesized peptide derived from the C-terminal region of human MLTK.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MLTK; ZAK; HCCS4; Mitogen-activated protein kinase kinase kinase MLT; Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixe
UniProt Protein Function:
ZAK: a mixed-lineage kinase containing a leucine-zipper (LZ) and a sterile-alpha motif (SAM). It is reported to activate the JNK/SAPK and NF-kappaB pathways.Protein type: Kinase, protein; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.25; TKL group; MLK family; MLK subfamilyChromosomal Location of Human Ortholog: 2q24.2Cellular Component: cytoplasm; nucleusMolecular Function: protein serine/threonine kinase activity; protein binding; MAP kinase kinase kinase activity; magnesium ion binding; ATP bindingBiological Process: cell death; activation of MAPKK activity; positive regulation of apoptosis; cytoskeleton organization and biogenesis; protein amino acid phosphorylation; activation of JNK activity; cell proliferation; response to radiation; DNA damage checkpoint; response to stress; cell differentiation; cell cycle arrest; cell cycle checkpoint
UniProt Protein Details:
NCBI Summary:
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Mitogen-activated protein kinase kinase kinase MLT
NCBI Synonym Full Names:
NCBI Official Symbol:
ZAKÂ Â
NCBI Official Synonym Symbols:
pk; AZK; MLT; MRK; MLK7; MLTK; mlklak Â
NCBI Protein Information:
mitogen-activated protein kinase kinase kinase MLT; HCCS-4; mixed lineage kinase 7; mixed lineage kinase-related kinase MRK-beta; human cervical cancer suppressor gene 4 protein; MLK-like mitogen-activated protein triple kinase; mixed lineage kinase with a leucine zipper and a sterile alpha motif
UniProt Protein Name:
Mitogen-activated protein kinase kinase kinase MLT
UniProt Synonym Protein Names:
Human cervical cancer suppressor gene 4 protein; HCCS-4; Leucine zipper- and sterile alpha motif-containing kinase; MLK-like mitogen-activated protein triple kinase; Mixed lineage kinase-related kinase; MLK-related kinase; MRK; Sterile alpha motif- and leucine zipper-containing kinase AZK
