The YWHAZ/YWHAB Polyclonal Antibody (PACO05319) is a valuable tool for research involving the YWHAZ and YWHAB proteins, which are members of the 14-3-3 family of proteins known to be involved in a wide range of cellular processes. This antibody, raised in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications.The YWHAZ/YWHAB Polyclonal Antibody specifically binds to the YWHAZ and YWHAB proteins, allowing for their detection and analysis in various cell types. This makes it an ideal choice for studies in signal transduction, cell cycle regulation, apoptosis, and other cellular processes where 14-3-3 proteins are known to play a role.
The YWHAZ/YWHAB proteins have been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. Understanding their functions and interactions is crucial for developing targeted therapies and diagnostic tools for these conditions. The YWHAZ/YWHAB Polyclonal Antibody provides researchers with a reliable means of studying these important proteins and their role in health and disease.
Antibody Name:
YWHAZ/YWHAB Antibody (PACO05319)
Antibody SKU:
PACO05319
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:20000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthesized peptide derived from human 14-3-3 β / zeta around the non-phosphorylation site of S184/186.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
YWHAZ; 14-3-3 protein zeta/delta; Protein kinase C inhibitor protein 1; KCIP-1; YWHAB; 14-3-3 protein β/α; Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
UniProt Protein Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
NCBI Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
