The YWHAZ Polyclonal Antibody (CAB14797) is a valuable tool for researchers studying the YWHAZ protein, a member of the 14-3-3 family known for its role in cell signaling and regulation. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the YWHAZ protein, this antibody allows for the detection and analysis of YWHAZ expression in a variety of cell types, making it ideal for studies in cell signaling, cancer research, and other fields of molecular biology.The YWHAZ protein is involved in a wide range of cellular processes, including cell cycle regulation, apoptosis, and protein trafficking.
Dysregulation of YWHAZ expression has been implicated in various diseases, such as cancer, neurodegenerative disorders, and cardiovascular disease. Understanding the function and activity of YWHAZ is crucial for developing targeted therapies and diagnostic tools for these conditions.Researchers can rely on the specificity and sensitivity of the YWHAZ Polyclonal Antibody (CAB14797) to accurately assess YWHAZ expression levels and localization in experimental samples. Whether investigating basic cellular processes or exploring potential therapeutic targets, this antibody is a valuable asset in the study of YWHAZ biology.
Antibody Name:
Anti-YWHAZ Antibody
Antibody SKU:
CAB14797
Antibody Size:
20uL, 50uL, 100uL
Application:
WB IHC
Reactivity:
Human, Mouse, Rat
Host Species:
Rabbit
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human YWHAZ (NP_001129171.1).
Application:
WB IHC
Recommended Dilution:
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:
Human, Mouse, Rat
Positive Samples:
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human YWHAZ (NP_001129171.1).
Purification Method:
Affinity purification
Storage Buffer:
Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene.
UniProt Protein Function:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
NCBI Summary:
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008]
