The YWHAQ Polyclonal Antibody (CAB2563) is a valuable tool for researchers studying YWHAQ, a member of the 14-3-3 family of proteins that play a crucial role in regulating signal transduction pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the YWHAQ protein, researchers can effectively detect and analyze its expression in a variety of cell types, making it an essential component for studies in cell signaling, cancer research, and neurobiology.
YWHAQ is known to interact with a wide range of target proteins, influencing various cellular processes such as cell cycle progression, apoptosis, and cell adhesion. Dysregulation of YWHAQ has been implicated in several diseases, including cancer, neurodegenerative disorders, and metabolic conditions. By understanding the role of YWHAQ in these diseases, researchers can potentially identify novel therapeutic targets and develop strategies for disease intervention and treatment.
Product Name:
14-3-3 Theta Rabbit Polyclonal Antibody
SKU:
CAB2563
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 49-149 of human 14-3-3 Theta (NP_006817.1).
Sequence:
KNVV GGRR SAWR VISS IEQK TDTS DKKL QLIK DYRE KVES ELRS ICTT VLEL LDKY LIAN ATNP ESKV FYLK MKGD YFRY LAEV ACGD DRKQ TIDN SQGA Y
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
Purification Method:
Affinity purification
Gene ID:
10971
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using 14-3-3 Theta antibody (CAB2563) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
