The YTHDC2 Polyclonal Antibody (CAB15004) is a valuable tool for researchers studying YTHDC2, a protein involved in RNA metabolism and gene expression regulation. This antibody, produced in rabbits, has been validated for use in Western blot applications and is highly reactive with human samples.YTHDC2 is a member of the YTH domain-containing family of proteins, which play important roles in RNA splicing and processing. The protein is known to interact with m6A-modified RNA, suggesting a role in the regulation of RNA stability and translation.
Research has implicated YTHDC2 in various cellular processes, including cell differentiation, embryonic development, and potential involvement in disease conditions.By using the YTHDC2 Polyclonal Antibody, researchers can detect and analyze the expression of YTHDC2 in different cell types and tissue samples. This antibody is a valuable tool for studies in molecular biology, developmental biology, and oncology, providing insights into the function and regulation of YTHDC2 in physiological and pathological processes.
Product Name:
YTHDC2 Rabbit Polyclonal Antibody
SKU:
CAB15004
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1131-1430 of human YTHDC2 (NP_073739.3).
endoplasmic reticulum, nucleus, perinuclear region of cytoplasm
Calculated MW:
160kDa
Observed MW:
160kDa
This gene encodes a member of the DEAH (Asp-Glu-Ala-His) subfamily of proteins, part of the DEAD (Asp-Glu-Ala-Asp) box family of RNA helicases. The encoded protein binds to N6-methyladenosine, a common modified RNA nucleotide that is enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. Binding of proteins to this modified nucleotide may regulate mRNA translation and stability. This gene may be associated with susceptibility to pancreatic cancer in human patients, and knockdown of this gene resulted in reduced proliferation in a human liver cancer cell line.
Purification Method:
Affinity purification
Gene ID:
64848
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using YTHDC2 Rabbit pAb (CAB15004) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
