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Yap1 Polyclonal Antibody (CAB24501)

SKU:
CAB24501
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
IHC
IF
€129 - €359
Frequently bought together:

Description

Yap1 Polyclonal Antibody (CAB24501)

The YAP1 Polyclonal Antibody (CAB24501) is a vital tool for researchers studying the YAP1 protein, a key regulator of cell growth and proliferation. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By targeting the YAP1 protein, researchers can effectively detect and analyze its expression in various cell types, making it ideal for studies in cell biology, cancer research, and regenerative medicine.YAP1, also known as Yes-associated protein 1, is a transcriptional coactivator that plays a crucial role in controlling cell growth, organ size, and tissue regeneration.

Dysregulation of YAP1 has been associated with various diseases, including cancer and liver disorders, making it an attractive target for therapeutic interventions. By gaining insights into the function of YAP1, researchers can develop targeted therapies aimed at modulating its activity in disease settings.Overall, the YAP1 Polyclonal Antibody (CAB24501) is a valuable tool for researchers looking to delve deeper into the mechanisms underlying cell growth and proliferation, with potential implications for cancer treatment and regenerative medicine advancements.

Product Name:Yap1 Polyclonal Antibody
Product Code:CAB24501
Reactivity:Human, Mouse, Rat
Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, IHC-P, IF/ICC, ELISA
Key Applications:Western blotting, Immunohistochemistry, Immunofluorescence
Recommended Dilution:WB 1:1000-1:5000, IHC-P 1:100-1:500, IF/ICC 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3.
Positive Samples:HeLa

This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants.

Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 139-488 of mouse Yap1 (NP_001164618.1).
Sequence:APAAQ HLRQS SFEIP DDVPL PAGWE MAKTS SGQRY FLNHN DQTTT WQDPR KAMLS QLNVP APASP AVPQT LMNSA SGPLP DGWEQ AMTQD GEVYY INHKN KTTSW LDPRL DPRFA MNQRI TQSAP VKQPP PLAPQ SPQGG VLGGG SSNQQ QQIQL QQLQM EKERL RLKQQ ELFRQ AIRNI NPSTA NAPKC QELAL RSQLP TLEQD GGTPN AVSSP GMSQE LRTMT TNSSD PFLNS GTYHS RDEST DSGLS MSSYS IPRTP DDFLN SVDEM DTGDT ISQST LPSQQ SRFPD YLEAL PGTNV DLGTL EGDAM NIEGE ELMPS LQEAL SSEIL DVESV LAATK LDKES FLTWL
Synonyms:Yap, Yki, Yap65, Yorkie
Calculated MW:52kDa
Observed MW:76kDa

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