The YAP1 Polyclonal Antibody (CAB21732) is a valuable tool for researchers studying the YAP1 protein, a key player in the Hippo signaling pathway that regulates organ size and tissue growth. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.YAP1, also known as Yes-associated protein 1, is a transcriptional co-activator that promotes cell proliferation and survival. Dysregulation of YAP1 signaling has been implicated in numerous cancers, making it an attractive target for therapeutic interventions.
The YAP1 Polyclonal Antibody enables researchers to study the expression and localization of YAP1 in cells and tissues, providing crucial insights into its role in tumorigenesis and cancer progression.With its high specificity and sensitivity, the YAP1 Polyclonal Antibody is an essential tool for those investigating the molecular mechanisms underlying cancer development and progression. Its ability to detect YAP1 in various sample types makes it an invaluable asset for studies aimed at unraveling the complex biology of YAP1 and its potential as a therapeutic target in cancer treatment.
Product Name:
YAP1 Polyclonal Antibody
SKU:
CAB21732
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 155-504 of human YAP1 (NP_001123617.1).
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10413
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and YAP1 knockout (KO) HeLa cells, using [KO Validated] YAP1 Rabbit pAb (CAB21732) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 20s.
