The YAP1 Polyclonal Antibody (CAB21333) is a valuable tool for research involving YAP1, a key transcriptional coactivator in the Hippo signaling pathway. This antibody, produced in rabbits, has high reactivity with human samples and is validated for use in applications such as Western blotting. It specifically binds to the YAP1 protein, allowing for precise detection and analysis in a variety of cell types.YAP1 is known for its role in regulating cell proliferation, differentiation, and apoptosis, making it a crucial player in cancer development and progression. Its dysregulation has been implicated in various types of cancer, making it a promising target for therapeutic intervention.
By studying the activity of YAP1, researchers can gain valuable insights into the mechanisms underlying tumorigenesis and potentially identify novel treatment strategies.Overall, the YAP1 Polyclonal Antibody (CAB21333) is an essential tool for scientists conducting research in the fields of cancer biology, cell signaling, and molecular biology. Its specificity and reliability make it ideal for investigating the functions of YAP1 and its implications in disease pathology.
Product Name:
YAP1 Polyclonal Antibody
SKU:
CAB21333
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 155-504 of human YAP1 (NP_001123617.1).
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10413
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using YAP1 Rabbit pAb (CAB21333) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
