The YAP1 Polyclonal Antibody (CAB1001) is a research tool specifically designed for studying YAP1, a key transcriptional regulator involved in cell growth and differentiation. This antibody, generated in rabbits, shows high reactivity with human samples and has been validated for Western blot applications. By binding to the YAP1 protein, this antibody allows for the detection and analysis of YAP1 expression in various cell types, making it a valuable tool for research in cell biology, cancer biology, and developmental biology.
YAP1, a downstream effector of the Hippo signaling pathway, plays a crucial role in regulating cell proliferation and survival. Dysregulation of YAP1 signaling has been implicated in various diseases, including cancer, making it an attractive target for therapeutic intervention. Understanding the mechanisms by which YAP1 functions can provide valuable insights into the development and progression of cancers and other diseases, leading to the identification of potential therapeutic targets for intervention.
Product Name:
YAP1 Rabbit Polyclonal Antibody
SKU:
CAB1001
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 155-504 of human YAP1 (NP_001123617.1).
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10413
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using YAP1 Rabbit pAb (CAB1001) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
