The YAF2 Polyclonal Antibody (PACO37670) is a valuable tool for researchers studying the YAF2 protein, which is known to play a role in gene regulation and chromatin remodeling. This antibody is produced in rabbits and has been validated for use in Western blot applications, making it ideal for detecting and analyzing YAF2 in a variety of cell types.YAF2 is a key component of the NuA4 histone acetyltransferase complex, which is involved in regulating gene expression by modifying chromatin structure.
Dysregulation of YAF2 has been linked to various diseases, including cancer and neurological disorders, making it a promising target for therapeutic interventions.By using the YAF2 Polyclonal Antibody, researchers can gain valuable insights into the function of YAF2 and its impact on cellular processes. This antibody is a valuable tool for studies in molecular biology, cancer research, and epigenetics, offering researchers a reliable means to study the role of YAF2 in health and disease.
Antibody Name:
YAF2 Antibody (PACO37670)
Antibody SKU:
PACO37670
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human YY1-associated factor 2 protein (1-204AA)
Immunohistochemistry of paraffin-embedded human colon cancer using PACO37670 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human glioma using PACO37670 at dilution of 1:100.
Background:
Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling.
Synonyms:
YY1-associated factor 2, YAF2
UniProt Protein Function:
YAF2: Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription, coactivator/corepressorChromosomal Location of Human Ortholog: 12q12Cellular Component: nucleoplasm; cytoplasm; nucleusMolecular Function: protein binding; zinc ion binding; transcription coactivator activity; transcription corepressor activityBiological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
