Ku80 Rabbit Polyclonal Antibody (CAB13369)
- SKU:
- CAB13369
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | Ku80 Rabbit Polyclonal Antibody |
SKU: | CAB13369 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 540-732 of human Ku80 (NP_066964.1). |
Sequence: | IEAK KKDQ VTAQ EIFQ DNHE DGPT AKKL KTEQ GGAH FSVS SLAE GSVT SVGS VNPA ENFR VLVK QKKA SFEE ASNQ LINH IEQF LDTN ETPY FMKS IDCI RAFR EEAI KFSE EQRF NNFL KALQ EKVE IKQL NHFW EIVV QDGI TLIT KEEA SGSS VTAE EAKK FLAP KDKP SGDT AAVF EEGG DVDD LLDM I |
Tested Applications: | WB IHC-P ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 |
Synonyms: | KU80; KUB2; Ku86; NFIV; KARP1; KARP-1; Ku80 |
Positive Sample: | HepG2,A-549 |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, nucleolus. |
Calculated MW: | 83kDa |
Observed MW: | 83kDa |
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Purification Method: | Affinity purification |
Gene ID: | 7520 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |