The XRCC4 Polyclonal Antibody (CAB1677) is a valuable tool for researchers studying XRCC4, a key protein involved in DNA repair and maintenance of genome stability. This antibody, produced in rabbits, is highly specific to XRCC4 in human samples and is validated for use in Western blot applications. By binding to XRCC4, this antibody allows for the detection and analysis of XRCC4 in a variety of cell types, making it ideal for studies in fields such as cancer biology and genetic research.XRCC4 is essential for the non-homologous end joining (NHEJ) pathway of DNA repair, playing a crucial role in the repair of DNA double-strand breaks.
Dysregulation of XRCC4 has been implicated in various diseases, including cancer and genetic disorders. Understanding the function and regulation of XRCC4 is important for developing targeted therapies and treatments for diseases associated with DNA damage and repair defects. The XRCC4 Polyclonal Antibody provides researchers with a reliable tool for investigating the roles of XRCC4 in health and disease.
Product Name:
XRCC4 Rabbit Polyclonal Antibody
SKU:
CAB1677
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human XRCC4 (NP_001304941.1?).
The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand breaks. This protein plays a role in both non-homologous end joining and the completion of V(D)J recombination. Mutations in this gene can cause short stature, microcephaly, and endocrine dysfunction (SSMED). Alternate transcript variants such as NM_022406 are unlikely to be expressed in some individuals due to a polymorphism (rs1805377) in the last splice acceptor site.
Purification Method:
Affinity purification
Gene ID:
7518
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using XRCC4 Rabbit pAb (CAB1677) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 1s.
