The XRCC3 Polyclonal Antibody (CAB2134) is a valuable tool for researchers studying XRCC3, a protein involved in DNA repair and maintenance. This antibody, produced in rabbits, shows high specificity towards human samples and has been validated for use in Western blot applications. By binding to XRCC3, this antibody allows for the detection and analysis of the protein in various cell types, making it suitable for research in genetics, cancer biology, and radiation biology.XRCC3 is a key player in the homologous recombination pathway, playing a crucial role in the repair of DNA double-strand breaks.
Mutations in XRCC3 have been associated with an increased risk of cancer and other genetic disorders, highlighting the importance of studying this protein in disease development and progression. The XRCC3 Polyclonal Antibody provides researchers with a reliable tool for investigating the function and regulation of XRCC3 in various biological pathways.
Product Name:
XRCC3 Rabbit Polyclonal Antibody
SKU:
CAB2134
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 62-346 of human XRCC3 (NP_001093588.1).
This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.
Purification Method:
Affinity purification
Gene ID:
7517
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of HL-60 cells, using XRCC3 antibody (CAB2134) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
