The XRCC1 Polyclonal Antibody (CAB0442) is specifically designed for research involving XRCC1, a critical protein involved in DNA repair processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the XRCC1 protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an ideal tool for studies in molecular biology, genetics, and cancer research.XRCC1 plays a crucial role in base excision repair, a fundamental mechanism for maintaining genomic stability and preventing mutations that can lead to cancer and other genetic disorders.
As such, understanding the function and regulation of XRCC1 is essential for advancing our knowledge of DNA repair mechanisms and developing targeted therapies for diseases related to DNA damage.By utilizing the XRCC1 Polyclonal Antibody (CAB0442), researchers can gain valuable insights into the role of XRCC1 in DNA repair pathways and its implications for human health. Its proven reliability and specificity make it a valuable tool for investigating the molecular mechanisms underlying genetic stability and disease progression.
Product Name:
XRCC1 Rabbit Polyclonal Antibody
SKU:
CAB0442
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 480-633 of human XRCC1 (NP_006288.2).
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Purification Method:
Affinity purification
Gene ID:
7515
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using XRCC1 Rabbit pAb (CAB0442) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
