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XRCC1 Rabbit Polyclonal Antibody (CAB0442)

SKU:
CAB0442
Product Type:
Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Epigenetics and Nuclear Signaling
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-XRCC1 Antibody CAB0442
  • Epigenetics and Nuclear Signaling Antibodies 1 Anti-XRCC1 Antibody CAB0442
€139 - €419
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Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:XRCC1 Rabbit Polyclonal Antibody
SKU:CAB0442
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse,Rat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 480-633 of human XRCC1 (NP_006288.2).
Sequence:NGAE DSGD TEDE LRRV AEQK EHRL PPGQ EENG EDPY AGST DENT DSEE HQEP PDLP VPEL PDFF QGKH FFLY GEFP GDER RKLI RYVT AFNG ELED YMSD RVQF VITA QEWD PSFE EALM DNPS LAFV RPRW IYSC NEKQ KLLP HQLY GVVP QA
Tested Applications:WB IHC-P IF/ICC ELISA
Recommended Dilution:WB,1:500 - 1:1000 IHC-P,1:100 - 1:500 IF/ICC,1:50 - 1:200
Synonyms:RCC; SCAR26; XRCC1
Positive Sample:NIH/3T3,Jurkat,Mouse brain,Mouse kidney,Rat brain
Conjugate:Unconjugated
Cellular Localization:Nucleus.
Calculated MW:69kDa
Observed MW:82kDa

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.

Purification Method:Affinity purification
Gene ID:7515
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using XRCC1 Rabbit pAb (CAB0442) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.

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