The XPNPEP2 Polyclonal Antibody (CAB10255) is a valuable tool for researchers studying XPNPEP2, a protein involved in various cellular processes, including peptide metabolism and blood pressure regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the XPNPEP2 protein, this antibody enables precise detection and analysis in a range of cell types, making it well-suited for investigations in areas such as cardiovascular biology and renal function.
XPNPEP2, also known as soluble aminopeptidase P, is a crucial enzyme that plays a role in the metabolism of peptides and proteins, as well as regulating blood pressure through its effects on vasoactive peptides. Dysregulation of XPNPEP2 activity has been linked to various diseases, including hypertension and cardiovascular disorders. By elucidating the functions of XPNPEP2, researchers can gain valuable insights into these conditions and potentially develop novel therapeutic strategies targeting this protein.
Product Name:
XPNPEP2 Rabbit Polyclonal Antibody
SKU:
CAB10255
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 22-240 of human XPNPEP2 (NP_003390.4).
293T,A-549,HepG2,HT-29,SW480,Mouse kidney,Mouse heart,Mouse small intestine,Rat kidney
Conjugate:
Unconjugated
Cellular Localization:
Cell membrane, GPI-anchor, Lipid-anchor.
Calculated MW:
76kDa
Observed MW:
76kDa
Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes.
Purification Method:
Affinity purification
Gene ID:
7512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using XPNPEP2 antibody (CAB10255) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
