XPC Rabbit Polyclonal Antibody (CAB8354)
- SKU:
- CAB8354
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IP
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | XPC Rabbit Polyclonal Antibody |
SKU: | CAB8354 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 700-940 of human XPC (NP_004619.3). |
Sequence: | GEVP YKMV KGFS NRAR KARL AEPQ LREE NDLG LFGY WQTE EYQP PVAV DGKV PRNE FGNV YLFL PSMM PIGC VQLN LPNL HRVA RKLD IDCV QAIT GFDF HGGY SHPV TDGY IVCE EFKD VLLT AWEN EQAV IERK EKEK KEKR ALGN WKLL AKGL LIRE RLKR RYGP KSEA AAPH TDAG GGLS SDEE EGTS SQAE AARI LAAS WPQN REDE EKQK LKGG PKKT KREK KAAA SHLF PFEQ L |
Tested Applications: | WB IHC-P IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | XP3; RAD4; XPCC; p125; XPC |
Positive Sample: | LO2,HeLa,293T,HT-1080,Jurkat |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasm, Nucleus. |
Calculated MW: | 106kDa |
Observed MW: | 130kDa |
The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 7508 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |