The XIRP2 Polyclonal Antibody (PACO58044) offered by AssayGenie is a valuable tool for researchers studying the XIRP2 protein, which is involved in cell junction organization and cytoskeletal dynamics. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.XIRP2, also known as Xin actin-binding repeat-containing protein 2, is a key player in maintaining cell structure and function, particularly in cardiac and skeletal muscle tissues. By targeting the XIRP2 protein, researchers can investigate its role in various cellular processes, making it a valuable asset for studies in cell biology and muscle physiology.
Understanding the function of XIRP2 is essential for unraveling its contribution to muscle development and contraction, as well as its potential involvement in diseases like muscular dystrophy and heart failure. With the XIRP2 Polyclonal Antibody from AssayGenie, researchers can delve deeper into the mechanisms underlying these conditions and pave the way for targeted therapeutic interventions.
Antibody Name:
XIRP2 Antibody (PACO58044)
Antibody SKU:
PACO58044
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Xin actin-binding repeat-containing protein 2 protein (2861-3004AA)
IHC image of PACO58044 diluted at 1:300 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
IHC image of PACO58044 diluted at 1:300 and staining in paraffin-embedded human skeletal muscle tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Protects actin filaments from depolymerization.
Synonyms:
Xin actin-binding repeat-containing protein 2 (Beta-xin) (Cardiomyopathy-associated protein 3) (Xeplin), XIRP2, CMYA3
UniProt Protein Function:
CMYA3: Protects actin filaments from depolymerization. Belongs to the Xin family. 7 isoforms of the human protein are produced by alternative splicing.Protein type: Unknown functionChromosomal Location of Human Ortholog: 2q24.3Cellular Component: cell junction; Z discMolecular Function: actin binding; alpha-actinin bindingBiological Process: intercellular junction assembly and maintenance; cardiac muscle morphogensis; actin cytoskeleton organization and biogenesis
