The XIAP Polyclonal Antibody is a valuable tool for researchers studying XIAP, a protein involved in the regulation of cell death and survival pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to XIAP, this antibody enables the detection and analysis of this critical protein in a variety of cell types, making it a key asset for studies in apoptosis, cancer research, and drug development.
XIAP, or X-linked inhibitor of apoptosis protein, plays a crucial role in preventing programmed cell death by inhibiting caspases, enzymes that promote cell death pathways. Dysregulation of XIAP has been implicated in various diseases, including cancer, making it a promising target for therapeutic intervention. Research into XIAP function is essential for developing novel treatments that exploit apoptosis pathways in cancer therapy and other disease contexts.
Product Name:
XIAP Polyclonal Antibody
SKU:
CAB21835
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 198-497 of human XIAP (NP_001158.2).
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Purification Method:
Affinity purification
Gene ID:
331
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse lung using XIAP Rabbit pAb(CAB21835) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
