The Anti-XIAP Polyclonal Antibody (CAB13277) is specially designed for researchers studying XIAP, a member of the inhibitor of apoptosis (IAP) family of proteins known for their role in regulating cell death and survival pathways. This antibody, generated in rabbits, exhibits high reactivity with human samples and is validated for Western blot applications. By binding specifically to XIAP, this antibody enables accurate detection and analysis of XIAP protein levels in various cell types, making it an essential tool for investigations in cell biology, apoptosis, and cancer research.XIAP, also known as X-linked inhibitor of apoptosis protein, is a key player in controlling programmed cell death processes and has been implicated in promoting cancer cell survival and drug resistance.
Targeting XIAP has emerged as a potential therapeutic strategy for treating cancer and other diseases characterized by dysregulated cell death pathways. Research on XIAP function is crucial for developing novel therapies that can selectively induce cancer cell death while sparing normal cells.Overall, the Anti-XIAP Polyclonal Antibody is a valuable asset for researchers seeking to unravel the complexities of XIAP biology and develop targeted interventions for diseases associated with aberrant cell death regulation.
Product Name:
XIAP Rabbit Polyclonal Antibody
SKU:
CAB13277
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human XIAP (NP_001158.2).
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.
Purification Method:
Affinity purification
Gene ID:
331
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Hep G2 cells using XIAP Rabbit pAb(CAB13277) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
