The X Antibody (PAC035134) is a highly specific and sensitive polyclonal antibody designed for research involving the target protein X. This antibody, raised in rabbits, demonstrates exceptional reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding to the X protein, this antibody enables precise detection and analysis in a variety of cell types, making it an invaluable tool for studies in immunology, cancer research, and beyond.X, also known as [specific function of X], plays a crucial role in [function or pathway related to X]. Its significance in [specific role of X] makes it a promising target for research exploring diseases like cancer, autoimmune disorders, and chronic inflammatory conditions.
Gaining a deeper understanding of the activity and regulation of X is essential for advancing therapeutic strategies that harness or modulate immune function in these disease contexts.Whether you are investigating basic immune responses or searching for new therapeutic targets, the X Antibody (PAC035134) offers the specificity and sensitivity needed for high-quality research results. Get started on your next project and uncover the secrets of X with confidence and precision using this reliable antibody.
Antibody Name:
X Antibody (PACO35134)
Antibody SKU:
PACO35134
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Hepatitis B virus genotype D
Immunogen:
Recombinant Hepatitis B virus genotype D Protein X protein (1-154AA)
Multifunctional protein that plays a role in silencing host antiviral defenses and promoting viral transcription. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding host CFLAR, a key regulator of the death-inducing signaling complex (DISC). Promotes viral transcription by using the host E3 ubiquitin ligase DDB1 to target the SMC5-SMC6 complex to proteasomal degradation. This host complex would otherwise bind to viral episomal DNA, and prevents its transcription. Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT.
Synonyms:
Protein X (HBx) (Peptide X) (pX), X
UniProt Protein Function:
Multifunctional protein that may modulate protein degradation pathways, apoptosis, transcription, signal transduction, cell cycle progress, and genetic stability by directly or indirectly interacting with hosts factors. Does not seem to be essential for HBV infection. May be directly involved in development of cirrhosis and liver cancer (hepatocellular carcinoma). Most of cytosolic activities involve modulation of cytosolic calcium. The effect on apoptosis is controversial depending on the cell types in which the studies have been conducted. By binding to human DDB1, may affect cell viability and stimulate genome replication. May induce apoptosis by localizing in mitochondria and causing loss of mitochondrial membrane potential. May also modulate apoptosis by binding human CFLAR, a key regulator of the death-inducing signaling complex (DISC). Moderately stimulates transcription of many different viral and cellular transcription elements. Promoters and enhancers stimulated by HBx contain DNA binding sites for NF-kappa-B, AP-1, AP-2, c-EBP, ATF/CREB, or the calcium-activated factor NF-AT. May bind bZIP transcription factors like CREB1 ().
