The WWP2 Polyclonal Antibody (CAB6789) is a valuable tool for researchers studying the WWP2 protein, a regulator of cellular processes related to protein degradation and signaling pathways. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot experiments. By specifically binding to the WWP2 protein, this antibody enables accurate detection and analysis in various cell types, making it ideal for studies in areas such as molecular biology and cancer research.
WWP2 is known for its role in the ubiquitin-proteasome system, where it targets proteins for degradation and plays a crucial part in maintaining cellular homeostasis. Dysregulation of WWP2 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising target for therapeutic interventions. Understanding the function and regulation of WWP2 is key to unraveling its significance in disease pathology and developing targeted treatments that could potentially benefit patients in the future.
Product Name:
WWP2 Rabbit Polyclonal Antibody
SKU:
CAB6789
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human WWP2 (NP_001257383.1).
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10.
Purification Method:
Affinity purification
Gene ID:
11060
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using WWP2 antibody (CAB6789) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
