The WWOX Polyclonal Antibody (CAB12653) offered by Assaygenie is a valuable tool for research involving the WWOX gene, which plays a crucial role in tumor suppression and genetic stability. This rabbit-raised antibody is highly reactive with human samples and has been validated for use in Western blot applications. By specifically binding to the WWOX protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cancer research and genetic disorders.The WWOX gene, also known as WW domain-containing oxidoreductase, is a tumor suppressor gene that is frequently altered in various types of cancers. Its role in maintaining genomic stability and regulating cell growth makes it a promising target for understanding cancer development and identifying potential therapeutic interventions.
Research on WWOX is essential for unraveling the mechanisms underlying tumorigenesis and for developing novel strategies for cancer treatment.By using the WWOX Polyclonal Antibody (CAB12653), researchers can gain valuable insights into the function and regulation of the WWOX gene, paving the way for advancements in cancer biology and personalized medicine. This antibody is a valuable resource for scientists studying the complex interplay between genetics, cancer, and cellular signaling pathways.
Product Name:
WWOX Rabbit Polyclonal Antibody
SKU:
CAB12653
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human WWOX (NP_057457.1).
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51741
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WWOX Rabbit pAb (CAB12653) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
