The WWOX Polyclonal Antibody (CAB12652) is a valuable tool for researchers studying the tumor suppressor gene WWOX (WW domain-containing oxidoreductase). This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds to the WWOX protein, allowing for the detection and analysis of WWOX expression in various cell types.WWOX is known to play a crucial role in DNA damage response, apoptosis, and tumor suppression, making it a key target for cancer research. Aberrant WWOX expression has been implicated in various cancers, making it a potential biomarker for diagnosis and prognosis.
Additionally, understanding the function of WWOX is essential for developing targeted therapies and personalized treatment strategies for cancer patients.Overall, the WWOX Polyclonal Antibody is a valuable tool for researchers studying the role of WWOX in cancer biology and DNA damage response pathways. Its high specificity and sensitivity make it an ideal choice for investigating the potential therapeutic implications of targeting WWOX in cancer treatment.
Product Name:
WWOX Rabbit Polyclonal Antibody
SKU:
CAB12652
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human WWOX (NP_057457.1).
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
51741
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WWOX Rabbit pAb (CAB12652) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
