The WWC2 Polyclonal Antibody (CAB18668) is a high-quality research tool designed for the study of WWC2, a protein involved in cell growth and cell polarity regulation. This antibody, generated in rabbits, exhibits strong reactivity with WWC2 in human samples and has been validated for use in Western blot applications. By targeting the WWC2 protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for investigations in cell biology and cancer research.
WWC2, also known as KIBRA, is a key regulator of the Hippo signaling pathway, which plays a crucial role in controlling cell proliferation and organ size. Dysregulation of WWC2 has been implicated in various diseases, including cancer and neurological disorders, making it a promising therapeutic target for drug development. By gaining insights into the function of WWC2, researchers can uncover potential new avenues for treating these diseases by targeting the Hippo pathway.
Product Name:
WWC2 Rabbit Polyclonal Antibody
SKU:
CAB18668
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 160-430 of human WWC2 (NP_079225.5).
This gene encodes a member of the WW-and-C2-domain-containing family of proteins. Members of this family have two N-terminal WW domains that mediate binding to target proteins harboring L/PPxY motifs, an internal C2 domain for membrane association, and C-terminal alpha protein kinase C binding sites and class III PDZ domain-interaction motifs. Proteins of this family are able to form homo- and heterodimers and to modulate hippo pathway signaling.
Purification Method:
Affinity purification
Gene ID:
80014
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WWC2 Rabbit pAb (CAB18668) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
