The WSS1 Antibody (PACO52186) is a highly specific polyclonal antibody designed for research involving WSS1, a protein involved in DNA repair and genome stability. This antibody, produced in rabbits, is optimized for use in various applications such as Western blotting, immunofluorescence, and immunohistochemistry.WSS1 is a key player in maintaining genomic integrity by facilitating DNA repair processes and preventing the accumulation of DNA damage. Mutations in WSS1 have been linked to increased susceptibility to DNA damage and genomic instability, which can contribute to the development of diseases such as cancer and genetic disorders.
Researchers can use the WSS1 Antibody to investigate the functions of WSS1 in cellular processes and disease mechanisms. By studying the expression and localization of WSS1 in different cell types and conditions, scientists can gain insights into the role of this protein in DNA repair pathways and potentially identify new therapeutic targets for diseases associated with genomic instability.
Antibody Name:
WSS1 Antibody (PACO52186)
Antibody SKU:
PACO52186
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Saccharomyces cerevisiae
Immunogen:
Recombinant Saccharomyces cerevisiae DNA-dependent metalloprotease WSS1 protein (1-269AA)
Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
Synonyms:
DNA-dependent metalloprotease WSS1 (EC 3.4.24) (DNA damage response protein WSS1) (SUMO-dependent isopeptidase WSS1) (Weak suppressor of SMT3 protein 1), WSS1
UniProt Protein Function:
Metalloendopeptidase that acts selectively on DNA-binding proteins. DNA is needed to bring the protease and substrates together to enable proteolysis. Involved in the repair of toxic DNA-protein cross-links (DPCs) such as covalently trapped topoisomerase 1 (TOP1) adducts on DNA lesions or DPCs induced by reactive compounds such as formaldehyde. Involved in DNA damage response and processing of stalled or collapsed replication forks by removing the covalently trapped TOP1 from chromatin. DPC proteolysis enables the repair of the lesions via downstream DNA repair pathways. May be recruited to DPCs via the SUMOylation of substrate proteins at damaged DNA sites.
