WRN Rabbit Polyclonal Antibody (CAB6855)
- SKU:
- CAB6855
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
Product Name: | WRN Rabbit Polyclonal Antibody |
SKU: | CAB6855 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1223-1432 of human WRN (NP_000544.2). |
Sequence: | CQTN SVQT DLFS STKP QEEQ KTSL VAKN KICT LSQS MAIT YSLF QEKK MPLK SIAE SRIL PLMT IGMH LSQA VKAG CPLD LERA GLTP EVQK IIAD VIRN PPVN SDMS KISL IRML VPEN IDTY LIHM AIEI LKHG PDSG LQPS CDVN KRRC FPGS EEIC SSSK RSKE EVGI NTET SSAE RKRR LPVW FAKG SDTS KKLM DKTK RGGL FS |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:1000 |
Synonyms: | RECQ3; RECQL2; RECQL3; WRN |
Positive Sample: | DU145,K-562 |
Conjugate: | Unconjugated |
Cellular Localization: | Nucleus, nucleolus, nucleoplasm. |
Calculated MW: | 162kDa |
Observed MW: | 200kDa |
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers.
Purification Method: | Affinity purification |
Gene ID: | 7486 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |