The WRB Polyclonal Antibody (CAB7000) is a valuable tool for researchers studying the WRB protein, which plays a key role in protein targeting to the endoplasmic reticulum (ER) membrane. This antibody, produced in rabbits, is highly specific to human WRB samples and has been validated for Western blot applications.WRB is a crucial component in the process of ER protein import and defects in WRB function have been linked to various human diseases, including congenital disorders of glycosylation.
By targeting the WRB protein, researchers can gain insights into ER protein transport mechanisms and potentially develop new therapies for ER-related diseases.With its high reactivity and specificity, the WRB Polyclonal Antibody is a valuable asset for studies in cell biology, molecular biology, and biochemistry. It enables precise detection and analysis of WRB in different cell types, providing essential information for understanding the role of WRB in protein trafficking and ER function.
Product Name:
WRB Rabbit Polyclonal Antibody
SKU:
CAB7000
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 30-100 of human WRB (NP_004618.2).
This gene is located in the candidate region for congenital heart disease (CHD) in Down syndrome (DS). It encodes a basic protein that functions as a receptor that promotes insertion of tail-anchored proteins in the endoplasmic reticulum membrane. This gene is located at a maternally-methylated differentially methylated region (DMR); however, its transcription may be biallelic, not imprinted. Alternative splicing results in different transcript variants. A pseudogene has been defined on chromosome 4.
Purification Method:
Affinity purification
Gene ID:
7485
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using WRB Rabbit pAb (CAB7000) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
