The Wolframin Polyclonal Antibody (CAB1705) is a valuable tool for researchers studying Wolframin, a protein involved in Wolfram syndrome, a rare genetic disorder characterized by diabetes mellitus, optic atrophy, and deafness. This antibody is raised in rabbits and is highly specific to human samples, making it ideal for use in Western blot applications.Wolframin is known to play a crucial role in regulating calcium homeostasis and endoplasmic reticulum (ER) stress responses, making it a key player in cellular function and survival. By targeting Wolframin with this polyclonal antibody, researchers can study its expression levels and localization in various cell types, providing insights into its function and involvement in disease pathogenesis.
The Wolframin Polyclonal Antibody is a valuable tool for researchers interested in understanding the molecular mechanisms underlying Wolfram syndrome and exploring potential therapeutic targets for this devastating disorder. Its high specificity, sensitivity, and reliability make it a key reagent for studies in genetics, endocrinology, and neurology.
Product Name:
WFS1 Rabbit Polyclonal Antibody
SKU:
CAB1705
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-285 of human WFS1 (NP_005996.2).
This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7466
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates, using WFS1 antibody (CAB1705) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
