The Wnt9b Polyclonal Antibody (PACO58040) is a vital tool for scientists studying the Wnt9b protein, which belongs to the Wnt family of signaling molecules that play crucial roles in development, tissue homeostasis, and disease. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.Wnt9b is a key player in the Wnt signaling pathway, which is involved in diverse biological processes such as cell proliferation, differentiation, and migration. Dysregulation of this pathway has been linked to various diseases, including cancer, neurodegenerative disorders, and developmental abnormalities.
By using the Wnt9b Polyclonal Antibody, researchers can investigate the expression and localization of Wnt9b in different cell types and tissues, providing valuable insights into its functions and potential therapeutic applications.This antibody is a valuable tool for scientists in the fields of developmental biology, cancer research, and regenerative medicine, as it allows for the precise detection and analysis of Wnt9b protein levels. By understanding the role of Wnt9b in health and disease, researchers can work towards developing novel therapies and interventions targeting the Wnt signaling pathway for various medical conditions.
Antibody Name:
WNT9B Antibody (PACO58040)
Antibody SKU:
PACO58040
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:200-1:500
Species Reactivity:
Human
Immunogen:
Recombinant Human Protein Wnt-9b protein (213-324AA)
IHC image of PACO58040 diluted at 1:200 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters (By similarity).
Synonyms:
Protein Wnt-9b (Protein Wnt-14b) (Protein Wnt-15), WNT9B, WNT14B WNT15
UniProt Protein Function:
WNT9B: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 17q21Cellular Component: proteinaceous extracellular matrix; extracellular space; extracellular regionMolecular Function: frizzled bindingBiological Process: positive regulation of catalytic activity; regulation of protein amino acid phosphorylation; response to retinoic acid; cell fate commitment; Wnt receptor signaling pathway; regulation of asymmetric cell division; in utero embryonic development; Wnt receptor signaling pathway, planar cell polarity pathway; multicellular organismal development; embryonic cranial skeleton morphogenesis; palate development; Wnt receptor signaling pathway through beta-catenin; cellular response to starvation; neuron differentiation; cell-cell signaling; ureteric bud branching; male genitalia development; regulation of tube size
UniProt Protein Details:
NCBI Summary:
The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. Study of its expression in the teratocarcinoma cell line NT2 suggests that it may be implicated in the early process of neuronal differentiation of NT2 cells induced by retinoic acid. This gene is clustered with WNT3, another family member, in the chromosome 17q21 region. [provided by RefSeq, Jul 2008]
