The Wnt8B Polyclonal Antibody (PACO20920) is a valuable tool for researchers studying the Wnt signaling pathway, a critical pathway involved in development, tissue homeostasis, and disease. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.Wnt8B, a member of the Wnt family of proteins, plays a crucial role in cell proliferation, differentiation, and migration. Dysregulation of the Wnt signaling pathway has been implicated in various diseases, including cancer, neurodegenerative disorders, and tissue repair processes.
By specifically binding to Wnt8B protein, this antibody allows for the sensitive detection and analysis of Wnt8B expression in a variety of cell types, making it an excellent tool for researchers exploring the role of Wnt signaling in development, disease, and therapeutic interventions. Understanding the function of Wnt8B and its interaction with other proteins in the pathway is essential for developing targeted therapies and interventions aimed at modulating Wnt signaling for therapeutic benefit.
Antibody Name:
WNT8B Antibody (PACO20920)
Antibody SKU:
PACO20920
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human WNT8B
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20920(WNT8B Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid, identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy.
Synonyms:
wingless-type MMTV integration site family, member 8B
UniProt Protein Function:
WNT8B: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. Belongs to the Wnt family.Protein type: Secreted; Secreted, signal peptideChromosomal Location of Human Ortholog: 10q24Cellular Component: extracellular region; extracellular spaceMolecular Function: frizzled bindingBiological Process: cell fate commitment; determination of dorsal identity; gastrulation; nervous system development; neuron differentiation; signal transduction; Wnt receptor signaling pathway
UniProt Protein Details:
NCBI Summary:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 95%, 86% and 71% amino acid identity to the mouse, zebrafish and Xenopus Wnt8B proteins, respectively. The expression patterns of the human and mouse genes appear identical and are restricted to the developing brain. The chromosomal location of this gene to 10q24 suggests it as a candidate gene for partial epilepsy. [provided by RefSeq, Jul 2008]
