The Wnt8A Monoclonal Antibody (PAC020919) is a valuable tool for researchers studying the Wnt signaling pathway. This antibody, generated in mice, specifically targets the Wnt8A protein, a key player in cell growth and differentiation. Its high reactivity with human samples and validation for use in various applications, including Western blot, immunofluorescence, and flow cytometry, make it versatile for a wide range of research purposes.Wnt signaling is a critical pathway involved in embryonic development, tissue regeneration, and cancer progression. Wnt8A, in particular, has been implicated in regulating cell fate decisions and maintaining stem cell pluripotency.
By targeting Wnt8A with this antibody, researchers can better understand its role in normal development and disease states, such as cancer and neurodegenerative disorders.Overall, the Wnt8A Monoclonal Antibody (PAC020919) provides a reliable tool for investigating the intricate mechanisms of the Wnt signaling pathway and its implications for various biological processes. Its specificity and versatility make it a valuable asset for studies in developmental biology, regenerative medicine, and cancer research.
Antibody Name:
WNT8A Antibody (PACO20919)
Antibody SKU:
PACO20919
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human WNT8A
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20919(WNT8A Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene.
Synonyms:
wingless-type MMTV integration site family, member 8A
UniProt Protein Function:
WNT8A: Ligand for members of the frizzled family of seven transmembrane receptors. May play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. Belongs to the Wnt family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted; Secreted, signal peptide; Extracellular matrixChromosomal Location of Human Ortholog: 5q31Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular regionMolecular Function: frizzled binding; receptor agonist activityBiological Process: neuron differentiation; response to retinoic acid; neural crest cell fate commitment; palate development; Wnt receptor signaling pathway through beta-catenin
UniProt Protein Details:
NCBI Summary:
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family, and may be implicated in development of early embryos as well as germ cell tumors. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2014]
