The Wnt5A Polyclonal Antibody (CAB12744) is a valuable tool for researchers studying the Wnt5A protein, a key regulator of cell signaling pathways. This antibody, produced in rabbits, boasts high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to Wnt5A, this antibody enables precise detection and analysis of the protein in various cell types, making it an excellent choice for studies in developmental biology, cancer research, and tissue regeneration.
Wnt5A is known for its diverse roles in controlling cell movement, polarity, and differentiation, making it a crucial player in various biological processes. Dysregulation of Wnt5A signaling has been implicated in several diseases, including cancer, cardiovascular disorders, and developmental abnormalities. By elucidating the functions of Wnt5A, researchers can gain insights into novel therapeutic approaches for targeting these conditions and understanding the underlying mechanisms of disease progression.
Product Name:
WNT5A Rabbit Polyclonal Antibody
SKU:
CAB12744
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 116-217 of human WNT5A (NP_003383.4).
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7474
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using (CAB12744) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
