WNT3 Rabbit Polyclonal Antibody (CAB9328)
- SKU:
- CAB9328
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Description
Product Name: | WNT3 Rabbit Polyclonal Antibody |
SKU: | CAB9328 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 166-355 of human WNT3 (NP_110380.1). |
Sequence: | VLVS REFA DARE NRPD ARSA MNKH NNEA GRTT ILDH MHLK CKCH GLSG SCEV KTCW WAQP DFRA IGDF LKDK YDSA SEMV VEKH RESR GWVE TLRA KYSL FKPP TERD LVYY ENSP NFCE PNPE TGSF GTRD RTCN VTSH GIDG CDLL CCGR GHNT RTEK RKEK CHCI FHWC CYVS CQEC IRIY DVHT CK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:200 - 1:2000 |
Synonyms: | INT4; TETAMS; WNT3 |
Positive Sample: | A-549,K-562,SKOV3,SGC-7901 |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted, extracellular matrix, extracellular space. |
Calculated MW: | 40kDa |
Observed MW: | 45kDa |
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene product. The mouse studies show the requirement of Wnt3 in primary axis formation in the mouse. Studies of the gene expression suggest that this gene may play a key role in some cases of human breast, rectal, lung, and gastric cancer through activation of the WNT-beta-catenin-TCF signaling pathway. This gene is clustered with WNT15, another family member, in the chromosome 17q21 region.
Purification Method: | Affinity purification |
Gene ID: | 7473 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |