The WNT2 Polyclonal Antibody (PAC020917) is specifically designed for research involving WNT2, a member of the Wnt signaling pathway that plays a crucial role in embryonic development, cell proliferation, and tissue regeneration. This antibody, produced in rabbits, is highly reactive with human samples and is validated for use in various applications, including Western blot and immunohistochemistry.WNT2 is a secreted glycoprotein that functions as a ligand for the Frizzled family of receptors, activating downstream signaling pathways that regulate gene expression and cell behavior. Dysregulation of the Wnt signaling pathway, including aberrant WNT2 expression, has been implicated in various diseases, including cancer, developmental disorders, and neurodegenerative conditions.
By using the WNT2 Polyclonal Antibody, researchers can detect and analyze WNT2 expression in different cell types and tissues, providing valuable insights into its role in normal physiological processes and disease states. This antibody is a valuable tool for studies in developmental biology, cancer research, and regenerative medicine, helping to advance our understanding of WNT2 function and its potential as a therapeutic target.
Antibody Name:
WNT2 Antibody (PACO20917)
Antibody SKU:
PACO20917
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse
Immunogen:
Synthetic peptide of human WNT2
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20917(WNT2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20917(WNT2 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.
Synonyms:
wingless-type MMTV integration site family member 2
UniProt Protein Function:
WNT2: Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family.
UniProt Protein Details:
Protein type:Cell development/differentiation; Extracellular matrix; Secreted, signal peptide; Cell adhesion; Secreted
Biological Process: lens development in camera-type eye; cell fate commitment; Wnt receptor signaling pathway; atrial cardiac muscle morphogenesis; Wnt receptor signaling pathway through beta-catenin; neuron differentiation; positive regulation of fibroblast proliferation; cell-cell signaling; positive regulation of mesenchymal cell proliferation; positive regulation of cell proliferation; positive regulation of transcription factor activity; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cardiac muscle cell proliferation; lung development
NCBI Summary:
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008]
