The WNK3 Polyclonal Antibody (CAB15507) is a valuable tool for researchers studying WNK3, a serine/threonine kinase involved in ion homeostasis and blood pressure regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the WNK3 protein, this antibody allows for precise detection and analysis in various cell types, making it an essential component for studies in physiology and cardiovascular research.
WNK3 is known for its role in regulating ion transport pathways that play a crucial role in blood pressure control. Dysregulation of WNK3 activity has been linked to hypertension and other cardiovascular disorders, making it a prime target for investigation in the development of new treatment strategies. Understanding the function of WNK3 is essential for uncovering the mechanisms underlying these conditions and identifying potential therapeutic interventions.
Product Name:
WNK3 Rabbit Polyclonal Antibody
SKU:
CAB15507
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 500-600 of human WNK3 (NP_065973.2).
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
65267
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of HAP1, using WNK3 antibody (CAB15507) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
