WISP3 Rabbit Polyclonal Antibody (CAB14812)
- SKU:
- CAB14812
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Product Name: | WISP3 Rabbit Polyclonal Antibody |
SKU: | CAB14812 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 42-260 of human WISP3 (NP_937882.1). |
Sequence: | TGPL DTTP EGRP GEVS DAPQ RKQF CHWP CKCP QQKP RCPP GVSL VRDG CGCC KICA KQPG EICN EADL CDPH KGLY CDYS VDRP RYET GVCA YLVA VGCE FNQV HYHN GQVF QPNP LFSC LCVS GAIG CTPL FIPK LAGS HCSG AKGG KKSD QSNC SLEP LLQQ LSTS YKTM PAYR NLPL IWKK KCLV QATK WTPC SRTC GMGI SNRV TNEN SNCE MRK |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | PPD; LIBC; PPAC; PPRD; WISP3; WISP-3 |
Positive Sample: | 293T,HT-29,DU145,HepG2,Mouse brain,Rat brain |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 39kDa |
Observed MW: | 41kDa |
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 8838 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |