The WISP3 Polyclonal Antibody (CAB14812) is a valuable tool for researchers studying the WISP3 protein, which is involved in bone development and maintenance. This antibody, generated in rabbits, has high reactivity with human samples and is validated for use in Western blot applications. By binding to the WISP3 protein, this antibody enables the detection and analysis of WISP3 in various cell types, making it ideal for studies in bone biology and related fields.WISP3, also known as CCN6, is a member of the CCN (Cyr61, CTGF, Nov) family of matricellular proteins that play important roles in tissue development and repair. WISP3 specifically regulates processes related to bone formation and mineralization, making it a key target for research into skeletal disorders and conditions like osteoporosis.
Understanding the function of WISP3 is crucial for developing new therapies for bone-related diseases and improving patient outcomes.Overall, the WISP3 Polyclonal Antibody (CAB14812) is a valuable tool for researchers investigating the role of WISP3 in bone biology and related fields. Its high reactivity, specificity, and validated performance in Western blot applications make it a reliable choice for studying the function and regulation of WISP3 in various biological contexts.
Product Name:
WISP3 Rabbit Polyclonal Antibody
SKU:
CAB14812
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 42-260 of human WISP3 (NP_937882.1).
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like domain. This gene is overexpressed in colon tumors. It may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Mutations of this gene are associated with progressive pseudorheumatoid dysplasia, an autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
8838
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using WISP3 Rabbit pAb (CAB14812) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
