The WISP2 Polyclonal Antibody (CAB7456) is a powerful tool for research involving WISP2, a member of the CCN family of regulatory proteins that play key roles in cell growth, differentiation, and inflammation. This antibody, derived from rabbits, has high specificity for human samples and has been validated for use in Western blot applications. By binding to the WISP2 protein, it allows for precise detection and analysis in a variety of cell types, making it essential for studies in biology, cell signaling, and cancer research.
WISP2, also known as CCN5, is a critical regulator of cell communication and tissue remodeling, influencing processes such as wound healing, fibrosis, and cancer progression. Its involvement in pathways related to cell proliferation and survival make it an intriguing target for investigation into various diseases and conditions. By understanding the function of WISP2, researchers can uncover new insights into cellular processes and potential therapeutic strategies for targeting these pathways.
Product Name:
WISP2 Rabbit Polyclonal Antibody
SKU:
CAB7456
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 164-250 of human WISP2 (NP_003872.1).
This gene encodes a member of the WNT1 inducible signaling pathway (WISP) protein subfamily, which belongs to the connective tissue growth factor (CTGF) family. WNT1 is a member of a family of cysteine-rich, glycosylated signaling proteins that mediate diverse developmental processes. The CTGF family members are characterized by four conserved cysteine-rich domains: insulin-like growth factor-binding domain, von Willebrand factor type C module, thrombospondin domain and C-terminal cystine knot-like (CT) domain. The encoded protein lacks the CT domain which is implicated in dimerization and heparin binding. It is 72% identical to the mouse protein at the amino acid level. This gene may be downstream in the WNT1 signaling pathway that is relevant to malignant transformation. Its expression in colon tumors is reduced while the other two WISP members are overexpressed in colon tumors. It is expressed at high levels in bone tissue, and may play an important role in modulating bone turnover.
Purification Method:
Affinity purification
Gene ID:
8839
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.09% Sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse ovary, using WISP2 Rabbit pAb (CAB7456) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
